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An Atlas of Investigation and Management
PULMONARY INFECTION
An Atlas of Investigation and Management
PULMONARY INFECTION Adam T Hill Consultant Physician Royal Infirmary of Edinburgh Scotland William AH Wallace Consultant Pathologist Royal Infirmary of Edinburgh Scotland Xavier Emmanuel Consultant Microbiologist Royal Infirmary of Edinburgh Scotland
CLINICAL PUBLISHING OXFORD Distributed worldwide by CRC Press Boca Raton London New York Washington D.C.
Clinical Publishing An imprint of Atlas Medical Publishing Ltd Oxford Centre for Innovation Mill Street, Oxford OX2 0JX, UK Tel: +44 1865 811116 Fax: +44 1865 251550 Web: http://www.clinicalpublishing.co.uk/ This edition published in the Taylor & Francis e-Library, 2006. “ To purchase your own copy of this or any of Taylor & Francis or Routledge’s collection of thousands of eBooks please go to http://www.ebookstore.tandf.co.uk/.” Distributed by: CRC Press LLC 2000 NW Corporate Blvd Boca Raton, FL 33431, USA E-mail: [email protected] CRC Press UK 23–25 Blades Court Deodar Road London SW15 2NU, UK E-mail: [email protected] © Atlas Medical Publishing Ltd 2005 First published 2005 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing of Clinical Publishing or Atlas Medical Publishing Ltd. Although every effort has been made to ensure that all owners of copyright material have been acknowledged in this publication, we would be glad to acknowledge in subsequent reprints or editions any omissions brought to our attention. A catalogue record for this book is available from the British Library. ISBN 0-203-02493-1 Master e-book ISBN
ISBN - (Adobe eReader Format) ISBN 1 904392 19 9 (Print Edition) The publisher makes no representation, express or implied, that the dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up-to-date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publisher do not accept any liability for any errors in the text or for the misuse or misapplication of material in this work.
Contents Acknowledgements
vi
Foreword
vii
Abbreviations
viii
1 Community-Acquired Pneumonia
1
2 Hospital-Acquired Pneumonia
41
3 Pneumonia in the Severely Immunocompromised Patient
49
4 Tuberculosis
73
5 Chronic Obstructive Pulmonary Disease
121
6 Bronchiectasis
130
7 Miscellaneous Respiratory Infections
149
Index
175
Acknowledgements To our wives, Lucy, Amanda and Jacintha, for their continuous support and understanding without which this atlas and many other things would never have been successfully completed.
Foreword Many of us have largely visual memories. This extensively illustrated book will make an immediate impact. For clinicians at any stage of training, that impact is likely to persist. Moreover the illustrations and their explanatory texts provide complementary reality behind the heavier paragraphs of standard textbooks. To more experienced clinicians, the book will be valuable as a reference, especially when they encounter less familiar clinical problems. Conversely, trainees in microbiology, radiology, and pathology will here find a rapid insight into the potential contributions fellow disciplines can make to a diagnosis. The brief texts on clinical and therapeutic aspects are written in clear straightforward English, again summarizing the essentials. The authors and publisher have done an excellent job. I wish the book all the success it deserves, Sir John Crofton Professor Emeritus University of Edinburgh Scotland
Abbreviations AFB
acid-fast bacilli
AIDS
acquired immune deficiency syndrome
CFT
complement fixation test
CMV
cytomegalovirus
COPD
chronic obstructive pulmonary disease
CT
computed tomography
EGG
electrocardiogram
ESAT
early secretory antigenic target
FEV1
forced expiratory volume in 1 second
FiO2
inspired oxygen concentration
G-CSF
granulocyte colony stimulating factor
IFNγ
interferon gamma
i.v.
intravenous
LDH
lactate dehydrogenase
MOTT
mycobacteria other than M. tuberculosis
MRSA
methicillin-resistant Staphylococcus aureus
NIV
noninvasive ventilation
PaO2
partial pressure of arterial oxygen
PAS
periodic acid Schiff
PCP
Pneumocystis carinii pneumonia
PCR
polymerase chain reaction
SaO2
oxygen saturation
TB
tuberculosis
TNF
tumour necrosis factor
VAP
ventilator-associated pneumonia
Chapter 1 Community-Acquired Pneumonia Introduction Internationally, community-acquired pneumonia is a common problem both for community and hospital physicians. It occurs with an annual incidence of about 5–11 per 1,000 adult population and rises with age, to about 34 per 1,000 population for patients aged over 75 years. The annual incidence of patients that require hospital admission varies from approximately 1–4 per 1,000 population. The mortality rates are low (50%. It is thus a common disease and can have considerable impact on health care resources. This section on community-acquired pneumonia, with illustrative radiology, microbiology, and pathology, discusses the investigation, diagnosis, and management of community-acquired pneumonia in adults. Key areas covered include the common causative organisms, patient presentation including severity assessment, a recommended investigation strategy, and treatment options. Finally, the complications of communityacquired pneumonia are illustrated with particular emphasis on the investigation, diagnosis, and management of lung abscess and pleural infection.
Aetiology In most cases of mild community-acquired pneumonia, a microbiological cause is not determined. When sputum samples are cultured by routine bacteriological methods, the commonest pathogen isolated is Streptococcus pneumoniae. Less commonly, Haemophilus influenzae or Moraxella catarrhalis may be cultured, particularly in patients with previous airways damage. Some important respiratory pathogens cannot be cultured by routine methods, but are usually detected by immunological or molecular methods. These, the so-called ‘atypical’ causes of pneumonia, include Mycoplasma pneumoniae, Legionella pneumophila, Chlamydia pneumoniae, Chlamydia psittaci, Coxiella burnetti, and respiratory viruses such as influenza viruses, adenoviruses, and respiratory syncytial virus. Most organisms associated with mild pneumonia can also cause severe communityacquired pneumonia. Particularly severe pneumonia with septic shock may result when viral infections, such as influenza, lead to secondary lung infections with virulent pathogens such as Streptococcus pneumoniae, Staphylococcus aureus, or Streptococcus pyogenes.
Pulmonary Infection
2
Presentation • Patients may have had preceding viral upper respiratory tract symptoms. • New onset of lower respiratory tract symptoms occurs (usually cough±sputum production [sometimes haemoptysis], breathlessness, fever, and sometimes pleurisy). • Systemic features are often present (general malaise, anorexia, sweating, fevers, shivers, or aches and pains). • Extrapulmonary symptoms can be present. • New onset confusion can arise in severe cases. • New focal chest signs occur. The clinical signs in practice can be highly variable (the classical teaching in lobar pneumonia is reduced expansion, coarse inspiratory crackles, reduced percussion, bronchial breathing, and increased vocal resonance in the affected lobe). • New chest radiographic consolidation is present. • There is no other explanation for illness. Overall, the likely aetiological agent cannot be accurately predicted from clinical features. Severity score To guide placement and treatment, it is helpful to stratify patients according to illness severity. Patients with severe pneumonia have two or more of the following: • New onset mental confusion. • Blood urea >7 mmol/l. • Respiratory rate ≥30/min. • Systolic blood pressure